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Prostrolane Inner B

Prostrolane Inner B

Innovative Dermal Filler with Sustained Release Technology & Novel Peptide Technology for reduction of localized fat accumulations.

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Description

Many people around the world are suffering from obesity because of eating habits, lack of exercise and/or congenital problems. Lipolysis is one of the most difficult clinical parts to solve effectively in the medical esthetic field.  Although many lipolytic products have been on the market for a long time, they were not meeting patients’ needs due to their poor efficacy and side effects.

With noble lipolytic peptides and its sustained release technology, we developed very safe and effective product which can give the most satisfaction to patients and doctors.

Caregen has been accomplished remarkable research achievements in targeted fat reduction and has developed Prostrolane Inner-B.
Prostrolane Inner-B is a sterile medical device, dermal resorbable implant that contains a Sodium hyaluronate and peptide complex (Nonapeptide-32, Pentapeptide-43, Tripeptide-41, Octapeptide-11). Prostrolane Inner-B is a transparent gel supplied in a glass syringe. The product is for single use only.

Site of application:
Face (double chin, jowl), abdomen, upper arms, love handles, thighs and knees.
Prostrolane Inner B injectable gel is indicated for deep dermis implantation for lipolysis of moderate to severe double chin, abdomen, buttocks, back of the thighs.

Active ingredientsActive ingredients:
– Nonapeptide-32: Promotes the metabolic cycles of glycolysis and gluconeogenesis.
– Pentapeptide-43: Decreases lipogenesis and promotes lipolysis.
– Tripeptide-41: Stimulates lipolysis and promotes cell regeneration of tissues.
– Octapeptide-11: Activates cell regeneration. Improves the appearance and tone of the skin.

GENERAL PRINCIPLES
Prostrolane Inner-B performs targeted fat reduction through activation of AMPK, PKA and ERK pathway which strongly increases lipolysis in accumulated lipid droplets by phosphorylation of ATGL and HSL, (increases secretion of triglyceride, free fatty acids).
In addition, Prostrolane Inner-B stimulates AMPK phosphorylation which leads inhibition of Lipogenesis by preventing PI3K-AK phosphorylation which is typical signaling pathway of triglyceride synthesis.

Looking at the benefits of Prostrolane Inner-B
1) The size of adipose tissues are reduced without fat cells necrosis, so the side effect is dramatically reduced compared to other products.
2) The product can give continuous and most effective lipolytic effect for 2 weeks with one injection.
3) The formulation is very soft which gives minimized pain and super comfortability to patients and doctors.
4) Unique and exclusive patented technology makes it difficult for competitors to copy, so it can have a
unique market position in the market.
5) The Product accelerating lipolysis, at the same time, and strongly down-regula ting lipogenesis.

Indications

Prostrolane Inner B injectable gel is indicated for deep dermis implantation for lipolysis of moderate to severe double chin, abdomen, buttocks, back of the thighs. Prostrolane Inner B lipolysis injection aims for reduction of localized fat accumulations.

Properties

Injection Depth
Subcutaneous layer of targeted area

Injection Volume
a. Abdomen: 12ml per session (Maximum 20ml)
b. Double Chin: 4ml per session (Maximum 5ml)
Inject 0.2ml (cc) to every targeted point

Recommendation
Recommend 1~2 times per week Multi-polar RF or Ultra Sound machine to massage the injected area for around 20~30minutes.
Recommend to do Treadmill Work out for 20~30minutes everyday

Treatment Method

Fat Reduction for Body Sliming

Induction of Lipolysis in Adipose Tissue

Tissue: abdominal fat, 100mg(tissue)/ml (24well plate)
Sample: 1ug/ml Inner B complex, 100ng/ml TNF-α (positive control)
Culture period: 48h

 

Inhibition of Lipogenesis

Cell line: 3T3-L1 pre-adipocyte cell line
Method: Oil red O staining
Sample: 0.1-1ug/ml Inner B complex 100ng/ml TNF-α (positive control)
Culture period: 6 days

Reduction of Localized fat accumulation

Before & Аfter Pictures

Double chin (2 syringes per session(3 sessions))

Abdomen (4 syringes per session (3 sessions) Result: -3 cm)

Love Handles (2 syringes per session (4 sessions))

Upper Arms (2 syringes per session (3 sessions))

Thigh (4 syringes per session (3 sessions))

Download PDF

Prostrolane Inner B Study Book

Platform Technology

Growth Factors
SUPERIORITY OF GROWTH FACTORS
– Competitive price based on mass production technology
– High efficacy and stability by double-layered capsulation technology
– High punity by sophisticated production facility and technical superiority

Biomimetic Peptides
ADVANTAGES OF BIOMIMETIC PEPTIDES
– Sustainable new biomimetic peptides development
– Competitive price based on mass production technology
– High punity by sophisticated production skill based on technical superiority

Skin Delivery System
DOUBLE-LAYERED CAPSULATION TECHNOLOGY
– High stability by double-layered structure
– High homogeneity : average diameter of particle is 140nm and over 80%
particles are below 100nm in size
– Effcient delivery of therapeutic cosmetic components into dermal layer

Skin Stem Cell Research
Skin Stem cell is a type of blast cell, Which can differentiate to various adult cells
including skin cell and hair cell. Caregen has focused on skin stem cell
differentiation to skin keratinocytes for Anti-aging.

Patents

– 21Growth Factors Registered in PCPC.

– 188 Biomimetic Peptides registered in PCPC.

– Multiple patents 123 patented materials in Korea, USA, Japan, China and Europe etc.

Certification & Accreditation

– Multiple patents over 100 patented materials in Korea, USA, Japan, China and Europe etc.

– CE Certificate, ISO 9001, 14001