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REVOFIL Plus

REVOFIL Plus

Ultra thin wall needle offers comfort injection for patients Filling deep wrinkles and lines. Harmonization of volume and lip contour.

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Description

HOW REVOFIL WORKS?

The cutting edge bio-technology

REVOFIL has both biphasic and monophasic physical characteristics introduced by combination of cutting edged biomimetic peptide technology and crossed linked HA which bring upgraded quality in gel viscosity and elasticity with softer operation.

REVOFIL contains higher concentration of free hyaluronic acid, linked with peptides, instead of PBS among cross-linked HA molecules which results in increased stability of HA gel Which is a safe material with natural compounds.

Long lasting, incomparable long duration: at least 10 ~ 12 months 

Strong inhibition of endogenous Hyaluronidase, increases duration of the gel in tissue.

REVOFIL makes up-regulation of endogenous collagen and hyaluronic acid to increase skin tightness and lifting. In overall, biomimetic peptide technology has endowed higher viscosity and elasticity, increased efficacy of sculpturing with longer lasting, increased gel stability and softer injection of hyaluronic acid gel.

Extraordinary firming and anti-wrinkle effect with natural looking

It involves an uncomplicated injection treatment with minimal scarring. With innovative active ingredients, REVOFIL makes you look natural and attractive by improving wrinkles.

The most Safe-dermal HA filler with peptides and highly qualified product  in the current market

High quality of hyaluronic acid and biomimetic peptides are safe with no-adverse effect and are biodegradable in the body.
This makes feel secure with a non-surgical and less invasive shaping and enhancement.

Immediate Results with a tailor-made aesthetic treatment proved by thorough clinical study

See the tab in this website “BEFORE & AFTER”. In addition it makes return quickly to daily activities with a short post-treatment recovery period.
Based on the noticeable functional Peptides, REVOFIL has shown positive regulation of endogenous collagen and hyaluronic acid synthesis in human fibroblasts and strong resistance to the enzyme which implies its longer lasting in tissue.

Dermal/Epidermal Cohesive Effect: Increased 81% Collagen 1 and 45% Hyaluronic Acid

REVOFIL has shown positive regulation of endogenous collagen and hyaluronic acid synthesis in human fibroblast cell.

Direct Inhibition of Hyaluronidase Activity: Decreased 90% Hyaluronidase Activity

REVOFIL contains a strong inhibitor of hyaluronidase. REVORIL, binds to the enzyme strongly and down-regulates the degradation of reticulated hyaluronic acid which implies increased duration of the gel in skin.

Production of Anti-oxidative stress and Photo-induced Cell Damaged

REVOFIL shows strong anti-oxidant effect against oxidative chemical and photo-damage induced UV in human dermal fibroblasts.

Decreased Enzymatic Degradation

REVOFIL showed strong resistance to the enzyme which implies longer lasting in skin compared to competitors. The result indicates that the duration of REVOFIL is much longer than other HA Dermal fillers.

Dermal/Epidermal Cohesive Effect: Increased 75% Collagen 1 and 48% Hyaluronic Acid

Direct Inhibition of Hyaluronidase Activity: Decreased 91% Hyaluronidase Activity

Protection of Photo-induced cell damage: Increased 60% protection

 

 

Indications

Filling deep wrinkles and lines. Harmonization of volume andlip contour.

Properties

– 23 mg/ml of HA
– 1ml prefilled syringe/pack
– 27G ½ needles included

Ultra thin wall needle offers comfort injection for patients Filling deep wrinkles and lines. Harmonization of volume and lip contour

Injection area: Fore Head, Nose Bridge, Nasolabial Folds, Marionette lines, Tear Troughs, Fine lines, Temporal region, Upper Cheeks, Cheeks, Hollow Cheek, Lip Lifting, Augmentation, Jaw, Chin, Mandibular region

Injection depth: Mid to Deep dermis
Duration term: 12 months on average *

Treatment Method

Needle: 27G 1/2

Indication: Correction of superficial wrinkles, fine lines, caved scar. Filling of all moderately pronounced wrinkles on the face and tissue.

Injection depth: Mid, Deep dermis

Injection area: Fore Head Nose Bridge Nasolabial Folds Marionette lines Tear Troughs Fine lines, Temporal region Upper Cheeks Cheeks, Hollow Cheek Lip Lifting, Augmentation Jaw, Chin, Mandibular region

Implant Duration Before touch up: 12 months on average

Injection Area:

 

Before & Аfter Pictures

REVOFIL Plus is designed for moderating fine wrinkles, lip augmentation, hollow cheeks and forehead. Flexible and elastic viscosity of HA gel increase volume and remove wrinkles on face.

Sex: Female
Age:
30’s
Product: REVOFIL Plus
Injection Area: Lip Augmentation

Sex: Female
Age:
30’s
Product: REVOFIL Plus
Injection Area: Nasolabial Folds

Sex: Female
Age:
40’s
Product: REVOFIL Plus
Injection Area: Nasolabial Folds

FAQ

If you want to look yourself more beautiful and younger, but want to avoid the pressure of surgery, REVOFIL could be right for you. This is a safe material with natural compounds in our body but sythesized outside the body.
Our research indicates that a large number of people would like to return their beauty in a natural, non-permanent way. They are also concerned about potential scarring or other aftereffects. REVOFIL answers these concerns Injecting REVOFIL is an uncomplicated with minimal time away from work and daily activities as a result.

Category: Revofil

The safety of REVOFIL has been thoroughly evaluated based on the standards of medical devices and then clinically proven. In our in-vivo test, one hundred seventy-two patients were injected with REVOFIL Ultra(56), REVOFIL Plus(86),REVOFIL Fine(30) and REVOFIL AQUASHINE and AQUASHINEBR were also clinically tested on the suitable standards for those who are aged 20 ~56.
All patients were satisfied after injection with no allergic reactions.
There’s no side effect of REVOFIL reported, the only issue could be from injection technic or the condition of treatment, you might experience some redness or a bit of swelling as being injected but it would be disappeared in a day.  Those reaction could depend on sensitivity of each skin.

Category: Revofil

1) Non comparably long duration: At least 10 ~ 12 months.

2) Extraordinary effects on collagen synthesis and skin firming by biomimetic peptides in Dermal Filler.

3) Safe and high quality product

Category: Revofil

We divided the REVOFIL into 3 types by viscosity for applications. (The cross linkage is based on the reaction time with cross linking agent hence the viscosity is different.)
The size of needles:
REVOFIL Ultra – 27G
REVOFIL Plus – 27G
REVOFIL Fine – 30G
REVOFIL Aquashine – 32G
REVOFIL Aquashine BR – 32G

Category: Revofil

There is no problem, it would be good for tissue relax.

Category: Revofil

Almost right after the injection. Ice pack cooling massage could help to reduce the redness and swelling.

Category: Revofil

The procedure takes around 30-90 minutes depending on the area treated and the quantity of gel injected. The result can be seen immediately.

Category: Revofil

We have the affirmative results reached by 99% in the clinical study. The effectiveness of treatment shows visible volumizing effect on lips, nose, hands and other parts, the patients wanted to be improved. Also, various kinds of facial wrinkles were decreased or disappeared especially around the eyes.

Category: Revofil

In-vitro test data compared REVOFIL to competitors in market, showed that Collagen and Hyaluronic Acid were less affected by enzymatic degradation.
REVOFIL breaks down slowly and the efficacy lasts longer.

Category: Revofil

REVOFIL brings aesthetic improvements on your face and body with fast and less painful procedure. The hyaluronic acid and biomimetic peptides maintain long-lasting volumizing and lifting efficacy.

Category: Revofil

The HA gel combined with biomimetic peptides enables facial implant to last longer than competitors and promotes collagen synthesis and anti-wrinkle & skin firming effects.

Category: Revofil

Biomimetic peptides provide additional ionic bonds to cross linked (or non-cross linked) HA leading to improvement of rheological properties of REVOFIL with better elasticity and stability. Hyaluronidase resistance is also enhanced by ionic bonds.

Category: Revofil

REVOFIL is basically biphasic gel which has stronger resistance to Hyaluronidase activity than monophasic. However, biomimetic peptides in REVOFIL are linked by ionic bondage with HA gel which makes texture as soft as monophasic.

Category: Revofil

Both of REVOFIL and REVOFIL AQUASHINE contains highly purified HA and basically they are different from whether HA was cross-linked or not.
Accordingly REVOFIL is more specialized augmentation and volumizing along with skin rejuvenation while REVOFIL AQUASHINE is mainly working for skin rejuvenation through hydration and brightening with cocktail of peptide complex, amino acids, multi-vitamin, minerals, etc.

Category: Revofil

AQUASHINE was designed for hydrating and rejuvenating efficacy with anti-aging cocktail. And AQUASHINEBR was focused on anti-pigmentation and skin brightening cocktail.

Category: Revofil

AQUASHINE:
-Reduce wrinkles and improve skin elasticity by generating new skin cells.
-Revitalize tired and dull skin by maximizing cell proliferation and reducing skin problem.
-Pure Hyaluronic acid moisturizes skin and tightens pores

AQUASHINEBR
-Reduce wrinkles and improve skin elasticity by generating new skin cells.
-Revitalize tired and dull skin by maximizing cell proliferation and reducing skin problem.
-Reduce and prevent hyper-pigmentation, down-regulates melanin synthesis, thereby reducing skin pigmentation, aged spots and freckles.
-Pure Hyaluronic acid moisturizes skin and tightens pores.

Category: Revofil

During our research we found that 1 ml is not enough for the treatment. Many doctors prefer to work with 2ml volume.

Category: Revofil

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Revofil

About Revofil

CAREGEN Research Center offers you perfect solution for face and tissue remodeling.
REVOFIL is a new generation filler that can last longer than other existing HA dermal fillers.
REVOFIL KEEPS AND MAINTAINS YOUR BEAUTY TODAY AND TOMORROW!

REVOFIL is made from high quality ingredients using innovative technology of CAREGEN Research Center – the leader of Bio actives and cosmeceuticals in the world. Advanced peptides development constantly provides you safe and perfect result saving your time, energy and money.

Product

We have succeeded in developing Innovative Dermal HA Filler. REVOFIL giving you a long lasting result generates endogenous HA, elastin, collagen, and other ECMs (Extracellular Matrix) refresh natural colors of your beauty.

REVOFIL present you long lasting desirable lines and features to Stay Longer, Stay Active and Stay Spectacular.

Philosophy

Cosmetic products should make you more beautiful and support your beauty as long as it possible and beyond. We are making sure to present such service to our customers.

Technology

CAREGEN has been developed its biotechnology innovative discoveries for more than 10 years to our valuable customers.
We know very well the miracle results of our biomimetic peptides.
Experience our new discoveries and share this experience with others.

Safety

The results and opinions from the clinical study done for CE certification under its strict regulation for REVOFIL Fine, Plus, Ultra, Aquashine and Aquashine BR are summarized as below:

1) In most clinical cases, tissue improvement was observed in various part of skin.
2) No major side effects requiring medical attention were observed.

From the clinical
observation made in this test with REVOFIL Fine, Plus, Ultra, Aquashine and Aquashine BR and broad experience of investigator in use of similar commercially available therapy, it can be said that REVOFIL Fine, Plus, Ultra, Aquashine and Aquashine BR possesses all physical, structural and biocompatibility properties that are required of a superior gel for used in skin restoring.

Name of Tests Conducted

1.Sterility Test 
This test was conducted to test suitability and validation for bacteriostasis and fungistasis.in accordance with “The Korean Pharmacopoeia
(9th Edition:2007)”

2. Endotoxin Test 
(LAL test)This test was conducted to detect and quantify endotoxins in REVOFIL in accordance with “The United Stated Pharmacopeia (USP 31)”.
<85>Bacterial Endotoxins test and “The Korean Pharmacopoeia
(9th Edition:2007)”

3. Skin sensitization Test
This test was conducted to evaluate the skin sensitizing potency of REVOFIL injection.

4. Acute Toxicity Test
This test was performed to investigate the acute toxicity when
REVOFIL injection.

5. Intracutaneous (intradermal) Reactivity Test
This test was performed to investigate irritation potency
(erythema and edema) for intradermal injection of REVOFIL.

6. Cytotoxicity Test
This test was conducted to evaluate the potential for cytotoxicity in-vitro in accordance with International Organization for Standardization 10993: Biological Evaluation of MedicalDevices, Part 5: Tests for
Cytotoxicity: in vitro Methods (ISO 10993-5).

7. Intracutaneous (intradermal) Reactivity Test
This test was performed to investigate irritation potency
(erythema and edema) for intradermal injection of REVOFIL.

8. 12-week Subcutaneous implantation test of REVOFIL (Injection)
This test was conducted to investigate the local response
(clinical sign, mortality and etc) of
subcutaneous tissue in REVOFIL injection.